Bird immunobiological parameters in the dissemination of the biofilm-forming bacteria Escherichia coli

Background and Aim: With the development of industrial maintenance technology, a group pathogens called avian pathogenic Escherichia coli (APEC) became very common. The initiation, development, outcome infectious process mediated by virulent APEC strains occur through decrease in colonization resistance intestine, an immunobiological marker homeostasis stability susceptible species. This study focused on pathogenetic features colibacillosis morphological E. coli. Materials Methods: Clinical, immunological, bacteriological, histological studies were conducted 15-day-old white Leghorn birds (n = 20). divided into two groups: Control (Group I; n 10) with intranasally inoculated 0.5 mL 0.9% NaCl solution experimental II; suspension at 1 billion/mL. Results: During biofilm formation, clusters microcolonies formed as gel-like intercellular matrix that accumulated due to cell coagulation. “glues” heteromorphic cells together forms structure densely packed arranged orderly manner growing different directions. reproduction coli, excessive growth was observed material isolated from poultry. Pathogenic implementing virulence factors adhered receptors erythrocytes, alveolocytes, enterocytes. Multicellular heterogeneous biofilms, united matrix, located apical poles respiratory tract alveolocytes enterocytes terminal ileum villi. Many bacteria exudate containing desquamated epithelial admixture mucus, polymorphonuclear leukocytes detected lumen birds’ abdominal organs. Invasive damaged layer, violated endothelial layer blood vessels, developed inflammatory hyperemia lamina propria digestive systems’ mucous membrane. A correlative dependence changes type delayed hypersensitivity reaction established. Signs accidental transformation thymus, atrophy bursa Fabricius, disseminated thrombosis, septic spleen developed. Moreover, toxic cardiomyocyte dystrophy, signs congestive vascular hyperemia, massive disintegration lymphocytes, macrophage reactions, perivascular edema resulting release plasma, shaped elements detected. Conclusion: escherichiosis primarily depend species microorganisms. One selected strains, O78:K80 displayed highest ability form biofilms. Its strong adhesion bird erythrocytes demonstrated. Deepening scientific knowledge interaction between eukaryotes prokaryotes will contribute better understanding aspects eventually find promising anti-adhesive drugs could reduce primary bacterial contamination vivo vitro. Keywords: colibacillosis,